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A single case report describes the use of steroids in a pediatric case of refractory CDAD. 35 As steroids have been successfully used for IBD, questions have arisen regarding the potential role of steroids in the inflammatory diarrhea of C. difficile. A 5-year-old boy received amoxicillin clavulanate for sinusitis and developed bloody diarrhea, which was positive for C.

After 3 days, the therapy was switched to oral prednisone, followed by a month-long taper.